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We carried out a meta-analysis to determine the effects of a longer term modest reduction in salt intake on blood pressure, plasma renin activity, aldosterone, noradrenaline (norepinephrine), adrenaline (epinephrine), total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, and triglycerides, as well as further subgroup analyses by ethnic group and sex.

We developed a search strategy (see appendix 1) to search electronic databases for randomised salt reduction trials: Medline from 1950 to November 2012; Embase from 1980 to November 2012; Hypertension Group Specialised Register; and Cochrane Central Register of Controlled Trials.

Meta-analysis by subgroup showed that in people with hypertension the mean effect was −5.39 mm Hg (−6.62 to −4.15, I=66%), respectively.

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Random effects meta-analyses, subgroup analyses, and meta-regression were performed.

Results Thirty four trials (3230 participants) were included.

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Inclusion criteria Randomised trials with a modest reduction in salt intake and duration of at least four weeks.

Data extraction and analysis Data were extracted independently by two reviewers.

They also implied that the fall in blood pressure in normotensive people was doubtful of public health benefit.

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